Description
Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR.
ANGPTL4 contains one fibrinogen C-terminal domain.
ANGPTL4 is a homooligomer, and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer.
The homooligomer unprocessed form is able to interact with the extracellular matrix.
ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis.
ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.
ANGPTL4 may exert a protective function on endothelial cells through an endocrine action